The Ketogenic Diet

introduction

• high-fat,

• adequate protein,

• lowcarbohydrate diet

• used for the treatment of intractable childhood epilepsy since the 1920s.

history

• Jesus
• Huge conklin-1921,water diet
• Geyelin-1921,AMA convention
• Phenytoin-1938
• Charlie foundation-1992

Mechanisms of action

• Ketone bodies-GABA

• Increased expression ofGlial fibrillary acidic protein(GFAP) in dentate gyrus of hippocampus

• Depressive effect on synoptic reorganisation

• Calorie restriction alone has been demonstrated in mice to impair seizure susceptibility. this may activate ATP sensitive potassium channels that may critically be involved in the regulation of seizure activity.

Indications

• several epilepsy syndromes,

• particularly in myoclonic astatic epilepsy, Dravets syndrome, and tuberous sclerosis

• focal and generalised epilepsy

…